Tissue Engineering

Tissue Engineering describes 'bottom-up' approaches originating from process engineering and material sciences to engineer tissue constructs from the seeding of adequate scaffolds with precursor cells. Its goal is to induce stem cells to differentiate into desired tissue cells that produce their respective extracellular matrix (ECM), by intelligent combinations of physical, chemical and biological factors. Still, such engineered tissue constructs have only limited capacities to replace whole organs because the artificial vascularization required remains challenging. However, smaller artificially engineered tissue constructs can already be employed as 'tissue patches' or serve as in vitro models, e.g. for compound screening. Besides such applications, the implementation of naturally obtained scaffolds for engineering of new tissues from decellularized matrices as well as the validation of correct ECM production in cell-seeded scaffolds represent further important research directions pursued at the MBT. Individual research projects covered by us are:

  • Multiphoton microscopical evaluation and optimization of ECM production in cell-seeded biomaterials
  • R&D project 'Multimodal tissue constructs for cell fitness testing'
  • Muscle tissue engineering from natural scaffolds: decellularization and bioreactor-design for recellularization

Details are given in the respective sub-pages.