Optical Imaging in Life Sciences


Optical Metrologies for Life Science Applications

Optical technologies that allow non-invasive, contact-free visualization and quantification of structure and function relationships in organs, cells, tissues and tissue-material composites have become an indispensable asset in Life Sciences. At the Institute of Medical Biotechology, both conventional microscopy technologies (e.g. fluorescence microscopy) are applied and novel multiphoton-based technologies are further developed and prepared for applications in the life science sectors, e.g. in Tissue Engineering.  For this, we closely collaborate with laser engineers (Institute of Photonical Technologies), the Erlangen Graduate School of Advanced Optical Technologies (SAOT) and medical engineering experts (Central Institute for Medical Engineering, ZIMT). In addition, Prof. Friedrich is one of the founding members of the Optical Imaging Center Erlangen (OICE) where novel optical technologies are being forged within so-called Explorative Research Units (ERU) that are then validated in collaboration with clinicians and biologists.

One of the since 2014 FAU-funded Emerging Fields Initatives (EFI) consists of a consortium of engineers (Institutes MBT, LPT), physicists (Max-Planck Institute for the Physics of Light) and physicians (Medical Clinics I, Department of Neurology). Coordinated by our institute MBT, activities focus on miniaturisation of multiphoton imaging for future microendoscopy application. This project called ADVENDO LIFFE (ADvanced ENDOmicroscopy in LIFE Sciences) aims to develop and construct a new seminal optical technology platform within the first five years that will then be translated into the clinics with the help of medical colleagues.

 

Optical technologies available and further engineered at our institute comprise:

  • Transmission microscopy
  • Fluorescence microscopy (Epifluorescence)
  • Multiphoton microscopy
  • Multifocal microscopy
  • High pressure imaging
  • Endomicroscopy development

 

Multiphoton Microscopy

Label-free Tissue Imaging